If humans were smart, we would bet on our ignorance.
That advice comes early in the Hebrew Bible. Adam and Eve’s banishment in chapters two and three of Genesis can be read as a warning that hubris is our tragic flaw. In the garden, God told them they could eat freely of every tree but the tree of knowledge of good and evil. This need not be understood as a command that people must stay stupid, but only that we resist the temptation to believe that we are godlike and can competently manipulate the complexity of the world.